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A decade of protein design leapfrog: David Baker discusses the scientific future of "designing proteins from scratch."

Date：Oct 16,2025

Author：Angelo - Reprint - SciPhi Synbio

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Industry trends

A decade of protein design leapfrog: David Baker discusses the scientific future of "designing proteins from scratch."

Nature Medicine | A joint team of professors from Shenzhen Institute of Technology has discovered that immune senescence is a key mechanism of resistance to immunotherapy.

Synthetic biology startups join forces with food giants to accelerate the scaled - up production of natural food colorants.

A team from the University of Pennsylvania has developed a generative AI model to design antimicrobial peptides from scratch accelerating the development of antibiotics.

A synthetic biology startup has raised 13 million US dollars to use microbial fermentation to produce plant bolites with multiple pipelines in progress.

A research team from Southeast University collaborates to construct a single-cell connectivity atlas of the mouse brain d on statistics.

Southern Medical University in collaboration with Sun Yat-sen University has developed magnetically driven biomimetic bacterial robots to achieve targeted drug delivery and immune regulation.

Nature highlights that the University of Chicago has achieved fluorescent protein spin qubits enabling quantum manipulation and imaging in vivo.

How do two startups Duckweed vs. Alfalfa crack the commercialization challenge of Rubisco?

Cover of Nature! A Chinese team designs ultra-strong underwater adhesive hydrogels using AI with strength exceeding 1 MPa.

The Qingdao Institute of Bioenergy and Bioprocess Technology has successfully sorted high-throughput yeast mutants unlocking efficient production of omega-7.

The team led by Cai Xia from the Chinese Academy of Sciences has developed a method for large - fragment DNA editing achieving precise and scar - free editing at the scale of thousands to millions of s in eukaryotic cells.

The Salk Institute has open-sourced an AI tool to precisely “identify” functional microproteins in the genome.

A team from China Pharmaceutical University has discovered a new dual-target antibiotic which may offer a solution to the problem of antibiotic resistance in superbugs.

Chinese scientists have cracked the mechanism of mold sensitization and targeting epithelial perforation signals may become a new strategy for anti-allergy.

Algae Feed to Prevent Cows from Belching? This Startup Raises Tens of Millions of Dollars to Focus on "Methane Killers"

Zhejiang University team optimizes aminoacyl-tRNA synthetase d on AI to achieve efficient incorporation of non-natural amino acids.

Helaina's Lactoferrin Production Reaches Ton-Scale and Has Been Adopted by Multiple Brands

A former DeepMind employee has unveiled a new AI model with a web version that can design proteins with just one click. Thirty experiments are equivalent to a million screenings.

A team from Jiangnan University has developed a novel targeted protein degradation system d on de novo protein design technology.

A gas fermentation startup is facing setbacks on the eve of scaling up and plans to sell its core assets.

The latest research in Nature reveals that specific gut microbiota can enhance the effectiveness of anti-cancer drugs with the efficacy of PD-1 being increased by three times.

Monash University uses AI to design proteins from scratch to block nutrient uptake and inhibit the growth of pathogens.

Tianjin University and other institutions have developed new technologies for mega-scale human genome DNA synthesis and cross-species transfer.

The University of Edinburgh has engineered E. coli to convert waste plastics into the painkiller acetaminophen with a yield of 92%

After screening over 2000 patterns scientists have identified specific patterns that make bacteria "slip" bidding farewell to infections caused by device implants

The NREL team in the United States recycles carbon fiber composites through a vinegar process generating recycled carbon fibers in just 2 hours

Nature reported the complete computational design of enzymes and Kemp increased the efficiency of enzyme elimination by a hundredfold

Nature's big News! Stanford's new strategy reveals the key genes for paclitaxel biosynthesis and reconstructs the heterologous synthetic pathway of bacartin III

29/5000 Lululemon has signed a 10-year agreement to purchase recycled nylon and polyester fibers

The team led by Academician Shan Yang from the Hunan Academy of Agricultural Sciences has modified yeast strains to eliminate the Crabtree effect and increase product yields

The former CEO of Google is betting on a startup to open source a 24-billion-parameter model focusing on the design of drug-like molecules

A team from Fudan University used bolic engineering to modify Max Cruvi yeast and synthesize inositol from starch

The team from the Institute of Process Engineering proposed a one-pot two-step multi-enzyme method to efficiently synthesize two types of human milk oligosaccharides

Cornell University has developed highly efficient biological leaching strains to facilitate the green extraction of rare earths

The Beihua team's bolic engineering modified halophilic strains to synthesize PHB with a yield of 64.9gL

Tan Tianwei et al. developed a microbial fermentation coupled with photocatalysis method to achieve the green synthesis of bio-d adipic acid

Xiamen University has published a breakthrough achievement in the efficient synthesis of branched-chain βγ -diols by microorganisms contributing to the goal of carbon neutrality

A brand-new microorganism has been discovered for the first time in China's space station! Species of the same genus have great potential in fields such as the production of bio-fertilizers and bioremediation

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Urine turns into a "biological mineral"! Lawrence Berkeley Laboratory has developed the "Bone Yeast" platform to synthesize high-value products at low cost

A major breakthrough has been made in a Nature journal: The University of Copenhagen has transformed a yeast "cell factory" to crack the final code of paclitaxel biosynthesis

Shanghai Jiao Tong University has modified Escherichia coli to achieve efficient synthesis of naringenin

Tianjin University has modified Saccharomyces cerevisiae achieving efficient synthesis of plant-d diterpenoids and reaching the highest yield to date

Danish company 21t.Bio has developed a mycotoxin-free Aspergillus oryzae strain ushering in a new era of precise fermentation protein production

The team from Jiangda University has modified Escherichia coli to achieve efficient production of the anti-cancer drug Perilla alcohol

Jinan University has discovered the key enzyme for the biosynthesis of dihydroartemisinic acid from artemisinic acid providing a more convenient and efficient approach for the production of artemisinin

Eth Zurich has designed photosynthetic biomaterials that can efficiently sequester carbon dioxide for over a year

MIT Tsinghua University and other institutions have modified Escherichia coli through bolic engineering to achieve the synthesis of diols with acetate as the substrate

On the same day two Nature sub-journals reported from Westlake University on the "plug-and-play" modification method of polyketo synthase which revolutionized the production of drugs and energy

A team from Zhejiang University of Technology has modified Escherichia coli to biosynthesize caffeic acid and chlorogenic acid from scratch

Peking University in collaboration with the Shenzhen Institute of Advanced Technology has launched a synthetic biology AI large language model successfully obtaining high-performance capping enzymes with a catalytic efficiency twice as high as that of commercial enzymes

New breakthrough in L-lactic acid production! A team from Jiangnan University has modified Saccharomyces cerevisiae to achieve efficient production without the need for neutralizing agents

The University of Waterloo in collaboration with Southern University of Science and Technology has constructed high-yield membrane vesicles of engineered bacteria breaking through the treatment bottleneck of IBD

Artificial sweeteners can also combat drug-resistant bacteria. Brunel University has revealed the key mechanism and they can also be used as wound dressings

An AI pharmaceutical startup is recruiting talents widely with Chinese scholars joining. It has proposed to build "virtual cells".

Praised by Bill Gates a California-d startup that uses carbon dioxide to produce butter is expected to launch its Series B financing by the end of the year

A Nobel Prize-winning team is in charge. An AI pharmaceutical company has raised 600 million US dollars and is expected to conduct clinical trials by the end of the year

Playing the ocarina painting ceramics... The humanistic atmosphere of Shenzhen Institute of Technology is so strong!

Nature | could rewrite the textbooks! The cooperation results of professors from Shenzhen University of Technology confirmed that cAMP is the second messenger of plant cells

Build a red education highland together! Shenzhen Science and Technology signed a cooperation agreement with the Party History Literature Research Office of the Municipal Committee

Minister of Education Huai Jinpeng presided over a research symposium on new research universities at Shenzhen University of Technology

Secretary Zhu Dijian led a team to visit a number of high schools in Hunan

Congrats! Pan Yi was elected as the 2024 Distinguished Fellow of the International Association of Engineering Technology

Neuron | A new way to treat Alzheimer's disease may be on the horizon

Deep Figure Recreation: "I look forward to the industrialization of the latest scientific research achievements in Shenzhen Polytechnic"

President speak! This class at Shenzhen Institute of Technology is full of "new"

16 academicians of both houses gathered together! The event kicked off at Shenzhen Polytechnic University

The freshman students made an academic report and the activity of Shenzhen Science and Technology was full of "science" flavor

Pair building

The Chinese Academy of Sciences International Scientific Program on Synthetic Cells was launched

A new mechanism of anti-depressant target 5-HT3R autonomous assembly was discovered by the team of Deep Science and Technology in collaboration with Max Planck of Germany

Trends in Biotechnology Design and R&D transformation of MAM materials d on regenerative bolic microenvironment

Shenzhen University of Technology and Peking University team publish the latest Nature Materials!

147 teams from more than 60 universities at home and abroad! The 3rd Synthetic Biology Innovation Competition was held in Shenzhen

The 18th Q-Bio Conference: Global scholars Explore New Frontiers of quantitative biology

National bio-manufacturing industry Innovation center start construction!

Zhu's team discovered a key mechanism in the lateral septal brain region that regulates reward and methamphetamine addiction

A "New Type of Research University" from the perspective of Central Media