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The team led by Cai Xia from the Chinese Academy of Sciences has developed a method for large - fragment DNA editing achieving precise and scar - free editing at the scale of thousands to millions of s in eukaryotic cells.

Date：Aug 06,2025

Author：Angelo - Reprint - SciPhi Synbio

First article  Next article

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Company News

The team led by Cai Xia from the Chinese Academy of Sciences has developed a method for large - fragment DNA editing achieving precise and scar - free editing at the scale of thousands to millions of s in eukaryotic cells.

A South Korean team has broken through traditional synthetic limitations to achieve ribosomal synthesis of cyclic peptides in vitro.

Zhao Huimin's team has developed a mitochondrial bolism decompartmentalization strategy which significantly increases the production of succinic acid.

The Cambridge team has restructured the genome of E. coli using only 57 codons which significantly enhances its antiviral capabilities.

A study published in Nature has confirmed that infections with COVID-19 and influenza can activate dormant cancer cells increasing the risk of cancer recurrence.

Rice University has developed a multi-channel bioelectronic sensor that can accurately detect multiple heavy l pollutants in water.

The first AI-designed gene editor has been published in Nature having edited the human genome. The team plans to open-source the most comprehensive CRISPR system data.

In just five months from proof of concept to gram-scale production the synthetic biology listed company NCT has achieved a breakthrough in synthesis with a purity of 99%.

Columbia University has used CRISPR transposase to precisely inactivate intestinal pathogens significantly improving the survival rate of mice.

Tianjin University has developed engineered probiotics in combination with electronic capsules to achieve integrated diagnosis and treatment of intestinal diseases.

A research team from Jiangnan University has engineered Pichia pastoris to achieve efficient conversion of methanol to farnesene.

A Chinese postdoctoral researcher as the first author the Nobel Prize-winning team utilized AI to design TCRs from scratch and is about to establish a company.

Two major companies under Flagship have laid off nearly a hundred people.

"Smart Bacteria" Conquer Kidney Stones! Stanford Team Repurposes Gut Bacteria to Precisely Degrade Oxalate in Urine

A team from Zhejiang University has launched a multimodal large language model that can design biomolecules d on human instructions.

Biodegradable and recyclable! Chen Zhaoji from Wuhan University and others have developed a "paper plastic" that can support a weight of 65 kg and degrade naturally in 180 days.

A team from Huazhong University of Science and Technology has developed a non-pathogenic bacteria-nanohybrid that works synergistically to inhibit tumors achieving a tumor targeting rate of 50%.

Chinese scholars turn food waste into treasure synthesizing 100% biodegradable bioplastic in two steps.

A team from the University of Pennsylvania used AI to decode animal venom discovering hundreds of potential antibiotics.

A startup is using synthetic biology to disrupt traditional poultry disease prevention. Its pioneering probiotic product is about to hit the market and it has raised $18 million in funding to drive commercialization.

Finnish companies are producing protein from air and a factory with an annual output of ten thousand tons is about to start production. It has already secured orders for 60% of its capacity.

A Chinese scholar serving as both the first author and corresponding author published a paper in *Cell* developing a photo-genetic platform to screen for broad-spectrum antiviral drugs which have been proven effective against multiple viruses.

A South Korean team has developed an engineered *Corynebacterium* platform breaking through the gram-level barrier in lutein production.

Mitsui Chemical has made a strategic investment in a British start-up and entered the field of artificial fat

The CRISPR patent battle has resumed. Can the Nobel laureate stage a comeback and regain the ?

Fruit flies transform into "protein factories". This start-up uses insects to replace bioreactors increasing efficiency by 30 times

Sumitomo Chemical announced the establishment of a bio-d LCP mass production technology and the product is expected to be launched in 2027

The new head of the FDA has taken tough measures: accelerating approval and bringing AI to work and the radical reform plan has sparked controversy

The Brazilian ethanol giant has teamed up with a Finnish start-up to produce bacterial protein using diluted distiller's grains as raw materials

Yuan Yingjin et al. modified Saccharomyces cerevisiae through bolic engineering achieving an efficient conversion from kaempferol to icaritin

Shenzhen Institute of Technology Unlocks the "new code" of synthetic biology: Six achievements are showcased at the scientific research achievements Release conference

Shenzhen Institute of Technology organized discussions on new paths for sharing scientific research resources

The production reached 35g/L and the bolic engineering strategy of the team of Jiangda Mu Wanmeng realized the biosynthesis of difucosyl lactose

Zhihuijun's team launched a full-stack robot learning platform with a success rate of more than 60% for complex tasks and the dataset has been open source

The University of Copenhagen customized synthetic isoprene analogs to obtain better properties of cannabinoids and flavourings

At the age of 18 he dropped out of school to start his own business and devoted himself to the development of plastic degrading enzymes with a cumulative investment of 250 million yuan

Based on cell bolism and morphological regulation Jiangnan University realized the efficient synthesis of hyaluronic acid with controllable molecular weight

Chinese Academy of Sciences team makes important progress in synthetic biology treatment of cancer! Breaking the "Morse Code" of tumors and bacteria

In the same period two Nature sub-journals Cornell University modified the built-in "kill switch" of Mycobacterium to enhance the safety of tuberculosis vaccine

Tsinghua Chen Guoqiang team engineered Vibrio natribosa to achieve efficient conversion of lysine into cadaverine

Shanghai Jiaotong University and others have developed new tools for systematic design of cell factories which can predict genetic modification targets and reduce development costs

Jaoyijian team of Jiangnan University published Nature sub-journal enzyme cascade reaction to achieve efficient synthesis of plant drug rotundine

Brazilian scientists have discovered a "super enzyme" in bagasse soil that helps cellulose degrade efficiently

Jay Keasling's team built a programmable biosynthesis platform d on polyketosynthase and sulfur reductase in Streptomyces albus to achieve efficient synthesis of diol amino alcohol and hydroxyl acid

Stanford Nvidia and others released the largest public AI biological model d on more than 100000 species gene sequence training is expected to accelerate the development of synthetic biology

Shandong University modified Yeyeria lipolytica to achieve efficient synthesis of natural anticancer compounds

Grok 3 is coming! Musk claims "the smartest AI on Earth" can 200000 Gpus subvert the AI landscape?

Tsinghua University Metabolic Engineering modified Escherichia coli to synthesize HMD and HDO from glucose

Duke University's synthetic biocondensates turbocharge bacteria for efficient protein production

China's biopharmaceutical industry is having a "DeepSeek moment" as it evolves from a manufacturing hub to an innovation hub

Xu Peng et al. engineered Yeyeria lipolysaccharides to detoxify plant food cyanoside and reduce the risk of poisoning

Where does DeepSeek's fancy writing come from? Insiders: Training data training strategies and iterative optimization are indispensable

Bacteria become a "living lens" and a team from a prestigious university has teamed up to create self-assembling biooptical materials that can survive stably for four months

Yuan Qipeng et al. from Beijing Chemical Industry established a synthetic pathway to achieve efficient synthesis of 1 5-pentanediol

Astaxanthin biosynthesis from Pichia pastoris by Zhang Wenming/Xinfeng Xue of Nanjing University of Technology

The combination of synthetic biology and Aspergillus Dongsheng Guo et al. Nanjing Normal University details the engineering strategy for the next generation of organic acid production

Rice University develops "smart cells" into Science enabling the design of synthetic phosphorylation circuits in human cells

Nvidia's most powerful graphics card 5090 debuts at CES! Simultaneous launch of multiple models and "personal AI supercomputing"

Zhejiang University's Ye Lidan team engineered Escherichia coli to biosynthesize nylon 12 monomer from glucose

High temperature electrostatic energy storage to meet important progress: Scientists use AI to assist the development of new heat-resistant polymers to provide a new solution to solve the energy storage needs of electric vehicles and avionics

The latest research of Beijing Institute of Radiation Medicine: a kind of engineering probiotics overexpressing antioxidant enzymes and intestinal adhesion fimbriae can effectively prevent and treat radiation enteritis by single oral administration

After 20 months d on three synthetic platforms the production efficiency of L-astaxanthin was increased by 300 times

Zhejiang University Lian Jianchang team built Pichia Pastoris cell factory and successfully achieved efficient synthesis of cholesterol sulfate

The team of Jiangnan University modified Serratia marclay and successfully realized the efficient synthesis of α-red myrrh alcohol

Leaving Google they built a platform to make quantum computing a reality and have received tens of millions of dollars in seed funding

Tianjin Institute of Industrial Biology Li Demao team modified Fusarium Venetian reduced the chitin content and improved the conversion rate of fungal protein

Chinese scholars put on a "Superman cloak" for E. coli to improve catalytic efficiency and sustainability and their research results were published in the Nature sub-journal

Scientists engineered seeds of camelina flax and shepherd's purse to achieve ultra-high levels of acetyl-tag accumulation which is expected to be used as a substitute for diesel

The team of Academician Chen Kefu of South China Institute of Technology developed a new type of bio-d plastic which has greatly improved the tensile strength and can be completely degraded within 80 days

Scientists have developed a new interventional brain-computer interface which can implant ultra-flexible electrodes without opening the brain and have successfully collected high-quality nerve signals

Protein large model ESM C released 6 billion parameters performance far exceeds 15 billion parameters of ESM2

Max Planck team creates new catalytic enzymes to improve the efficiency of anabolic pathways results published in Nature

Unilever is committed to ESG goals by partnering with agrochemical giants to develop sustainable raw material ingredients

Scientists put forward a "one-pot microfluidic manufacturing" system to prepare a variety of complex ceramic particles which can be used as precision parts of MEMS

Founded by a former Silicon Valley engineer Synthetic Biology company raises $73 million to develop protein engineering using AI

With a 93% similarity to the resting state signal of the human brain scientists have developed a digital twin brain platform to simulate the structure and function of the human brain

An international team has discovered new strains of cyanobacteria isolated from volcanic undersea vents that help sequester carbon in oceans and factories

The International Federation of Synthetic Cells was established

DNA storage has made breakthroughs and the Peking University team has stored images with "movable type printing" significantly improving capacity and efficiency

A Chinese scholar serving as both the first author and corresponding author published a paper in Cell developing a photo-genetic platform to screen for broad-spectrum antiviral drugs which have been proven effective against multiple viruses.

A South Korean team has developed an engineered Corynebacterium platform breaking through the gram-level barrier in lutein production.